Andrew cox methods


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Maybe I'm missing something, but it looks like 5 is fairly far from the optimum (it implies a predicted probability of ) and in a part of the parameter space that is locally linearly flat. I'm not as sure about IWLS algorithms, but with EM, I often find that starting the algorithm "close" to boundary (such as ) will run toward the boundary instead of away, due to numerical errors. It is terribly annoying. Any reason to not start at the coefficients from a linear model?

Golgi impregnation is unique in its ability to display the dendritic trees of large numbers of individual neurons. However, its reputation for inconsistency leaves many investigators reluctant to embrace this methodology, particularly for the study of formalin-fixed human brain tissue. After reviewing the literature, testing a variety of technical variations, and discussing the procedure with experienced practitioners, we have concluded that much of the unpredictability can be removed by matching the Golgi technique to the conditions that were used for fixation of the tissue. Briefly fixed tissues worked best with the rapid Golgi technique, which includes osmium during the initial chromation step, and with the Golgi–Cox method, which includes mercuric chloride during chromation. For tissues that have been fixed for several years or even for several decades, superior results are obtained with the Golgi–Kopsch technique, using multiple changes of a chromation solution that contains paraformaldehyde. In the Golgi–Kopsch technique, pH should be used to monitor the reduction of Cr 6+ to Cr 3+ , which is a crucial determinant of successful chromation. With any Golgi technique, agitation throughout the impregnation helps to avoid precipitates and to improve the quality of impregnation. When the appropriate method is chosen, Golgi impregnation is a useful technique for the neuropathologist.

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Reuse: Clean out jam or jelly jars and reuse them as drinking glasses — they're the perfect size for little hands, says Pinkson. And incorporate empty paper towel rolls into your youngster's next art


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